Los Angeles Angels starting pitcher Shohei Ohtani high fiving teammates

Apr 28, 2022; Anaheim, California, USA; Los Angeles Angels starting pitcher Shohei Ohtani (17) high fives shortstop Andrew Velazquez (4) after the final out of the ninth inning defeating the Cleveland Guardians at Angel Stadium. Mandatory Credit: Jayne Kamin-Oncea-USA TODAY Sports

  • The Chicago White Sox are -125 home favorites over the Los Angeles Angels in an American League game scheduled for Friday, April 29
  • LA has won two in a row and four of five games from the ChiSox
  • Below, see the Angels vs White Sox odds and best bets for Friday

Years ago, the Chicago White Sox and Los Angeles Angels used to play in the same division. Luckily for the ChiSox, that’s no longer the case.

While Chicago is the beast of AL Central, they play absolutely ghastly when facing the Angels. LA is 4-1 over the past five games between the two teams. At Chicago, the Angels maintain a 7-2 edge through the past nine meetings.

Regardless, it’s the hometown White Sox who are set by oddsmakers as the -125 home favorites as these two old rivals renew hostilities on Friday. LA is 5-0 straight up through their past five games.

Angels vs White Sox Odds

Team Moneyline Runline Total
Los Angeles Angels +105 +1.5 (-200) O 7 (-10)
Chicago White Sox -125 -1.5 (+170) U 7 (-115)

Odds as of April 28th at Caesars Sportsbook.


First pitch for Friday’s game at Guaranteed Rate Field is set for 7:10pm ET. The forecast is calling for cloudy skies, 12 mph wind and a temperature of 56 degrees.

The White Sox are the -190 odds-on favorites to win the AL Central in the MLB Division odds. Meanwhile, at a betting line of +320, the 13-7 Angels may offer value to win the AL West title.

Los Angeles vs Chicago Probable Pitchers

Bettors get a quality matchup of ace righthanders on the mound, as Noah Syndergaard goes for the Angels against Lucas Giolito of the White Sox.

Syndergaard has already made more starts this season than last season, when continued recovery from Tommy John surgery limited him to two games with the New York Mets. So far, with his rebuilt new arm, Syndergaard is looking like his old self.

Syndergaard, who didn’t pitch at all in 2020, is showing an impressive 0.82 WHIP. He’s allowed 10 hits and four earned runs in 17 innings while striking out 11.

He’s only faced the White Sox twice in his career, including one start and is 0-0 with a 0.00 ERA. Over the course of 8.1 innings, he struck out 13, walked one and allowed five hits.

Syndergaard vs Giolito

2-0 Record 0-0
2.12 ERA 1.13
2.21 xERA 3.21
0.82 WHIP 1.25
2.75 SO/W Ratio 3.00

Giolito has allowed just five hits and one earned run in eight innings of work. He missed two starts after feeling a tweak in his lower left abdominal area on three straight pitches in the opening day game against the Detroit Tigers on April 9.

Following a stint on the IL, Giolito returned to action April 24. He worked another four innings and threw 76 pitches in a start against the Minnesota Twins. He’s struck out 15 while walking just five over his eight innings of work.

Giolito is 2-0 with a 3.81 ERA in five career starts against the Angels. But he’s just 17-24 with a 4.17 ERA in his career at Guaranteed Rate Field.

Batting Average vs Starting Pitchers

White Sox Batters Batting Average vs Syndergaard Angels Batters Batting Average vs Giolito
Jose Abreu .000 Jo Adell .000
Tim Anderson .000 Matt Duffy .000
Jake Burger .000 Brandon Marsh .000
Adam Engel .333 Jack Mayfield .000
Leury Garcia .200 Shohei Ohtani .286
Yasmani Grandal .286 Anthony Rendon .000
Josh Harrison .250 Max Stassi .222
Reese McGuire .000 Kurt Suzuki .000
Danny Mendick .000 Mike Trout .200
AJ Pollock .400 Andrew Velazquez .000
Luis Robert .000 Tyler Wade .000
Gavin Sheets .000 Jared Walsh .250
Andrew Vaughn .000 Taylor Ward .250

White Sox catcher Yasmani Grandal is just 2-for-7 off of Syndergaard but one of those hits was a solo homer. Outfielder AJ Pollock is 2-for-5 (.400) with an RBI. Outfielder Adam Engel is 1-for-3 (.333).

Angels designated hitter Shohei Ohtani, outfielder Mike Trout, first baseman Jared Walsh and catcher Max Stassi have all homered off of Giolito. Ohtani is 4-for-14 (.286) when facing him.

Angels vs White Sox Prediction

Take the solid record the Angels have posted both overall and in Chicago against the White Sox. then factor in how scintillating Syndergaard is looking on the bump.

Finally, take into account how the 7-10 White Sox are scuffling so far this season and that Giolito is likely to be on a pitch count and the upset play makes perfect sense.

Pick: Los Angeles Angels moneyline (+105)

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