Colorado center Nathan MacKinnon scoring a goal on St Louis goalie Ville Husso

May 25, 2022; Denver, Colorado, USA; Colorado Avalanche center Nathan MacKinnon (29) scores a goal past St. Louis Blues goaltender Ville Husso (35) and defenseman Nick Leddy (4) defends in the third period in game five of the second round of the 2022 Stanley Cup Playoffs at Ball Arena. Mandatory Credit: Isaiah J. Downing-USA TODAY Sports

  • The Colorado Avalanche and St. Louis Blues faceoff in Game 6 on Friday, May 27th
  • Colorado is road favorites in the Game 6 Avalanche vs Blues odds
  • Read below for Avalanche vs Blues Game 6 odds, lines and pick

The Colorado Avalanche will look to eliminate the St. Louis Blues in Game 6 on Friday, May 27th. Puck drop is 8:00 pm ET at Enterprise Center, with TNT and CBC carrying the broadcast.

Colorado is listed as -182 road favorites in the Game 6 Avalanche vs Blues odds. The total is set at 6.5 as the Blues aim to stave off elimination in their home building.

Let’s analyze the Game 6 Avalanche vs Blues odds and offer you our betting pick.

Avalanche vs Blues Odds

Team Puck Line Total Moneyline
Colorado Avalanche -1.5 (+135) O 6.5 (-114) -182
St. Louis Blues +1.5 (-165) U 6.5 (-106) +150

Odds as of May 26th at Barstool Sportsbook.



The spread sees the Avalanche listed on the puck line at +135 odds to win by more than one goal, while the Blues are -165 to keep the game within two goals.

With Colorado leading the series 3-2, the Avs are priced as heavy -1000 favorites in the Avalanche vs Blues series odds.

Avalanche vs Blues Betting Analysis

The Avs will have a second chance to eliminate the Blues from the NHL postseason Friday after failing to get the job done in Game 5 on Wednesday. Nathan MacKinnon scored a hat trick, but it wasn’t enough in a 5-4 overtime victory for St. Louis.

Although the Blues staved off elimination Wednesday, the Avalanche still hold the edge in the NHL odds. Colorado has controlled 60% of the shot attempts at five-on-five in the series and have a 57.7 XGF%.

The Avs are clearly the more talented team, but there are some minor concerns heading into Game 6. Goalie Darcy Kuemper has allowed eight goals in back-to-back starts, as the Avs’ blueline has taken a hit with the season-ending injury to Samuel Girard.

The good news for Colorado is MacKinnon had his best performance of the postseason Friday and should carryover some of that momentum into Game 6. The Avs’ superstar had been held to just three assists in the series prior to his hat trick performance.

Colorado vs St. Louis Betting Trends

With the series shifting back to St. Louis, there are some betting trends to note for Avalanche vs Blues. Colorado won both games vs the Blues at Enterprise Center in this series and are 4-0 in their last four road games overall.

The Avalanche also tend to respond well after tough losses, as Jared Bednar’s club is 10-2 in their last 12 games after allowing five or more goals the previous game. That resilliency is one of the reasons the Avs remain favored in the Stanley Cup odds.

When it comes to head-to-head trends for Avalanche vs Blues, the game total and road team are where the value is at. Colorado has won five straight against the Blues in St. Louis and the “over” has cashed in every one of those meetings.

Game 6 Avalanche vs Blues Pick

Colorado missed a chance to eliminate the Blues in Denver, but they can punch their ticket to the Western Conference Final with a victory at Enterprise Center. The Avs’ five straight victories in St. Louis indicate they should be able to get the job done Friday.

Kuemper’s recent struggles are a tad concerning, but keep in mind Blues’ goalie Ville Husso has allowed four or more goals in each of his past five starts. Husso owns a .884 playoff save percentage and hasn’t been able to stymie this high-powered Colorado offense.

The Avs have controlled the play in this series and should continue their road success in the NHL odds. After blowing a late lead Wednesday, look for Colorado to start strong again in Game 6 but not let off the gas this time.

Bet the Avs regulation line at -109 in the Avalanche vs Blues Game 6 odds at Barstool Sportsbook.

Pick: Avalanche Three-Way Line (-109)


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