Austin Slater basehit

San Francisco Giants’ Austin Slater runs to first on a single during the third inning of the team’s baseball game against the Washington Nationals, Friday, April 22, 2022, in Washington. (AP Photo/Nick Wass)

  • The Giants vs Nationals odds favor San Francisco as -165 moneyline favorites on Saturday (April 23, 1:05pm ET)
  • San Francisco will give the ball to Alex Wood (1-0, 1.93 ERA), while Washington will counter with Aaron Sanchez (2021 stats: 1-1, 3.06 ERA)
  • Read below for the Giants vs Nationals odds, analysis and betting prediction

Game 2 of the Giants and Nationals series is set for Saturday afternoon in DC, after San Francisco cruised to victory on Friday in the series opener. The Giants smacked 12 hits en route to a 7-1 win, and oddsmakers are leaning towards San Fran again on Saturday.

Giants vs Nationals Odds

Team Moneyline Runline Total
San Francisco Giants -165 -1.5 (-105) O 8.5 (-115)
Washington Nationals +135 +1.5 (-115) U 8.5 (-105)

Odds as of April 22nd at Caesars Sportsbook.

The Giants opened up as a -165 moneyline favorite, in a contest that features a total of 8.5 runs. First pitch is scheduled for 1:05pm ET at Nationals Park in Washington, DC, with a sun-cloud mix and 68 degree temperatures in the forecast.

Probable Pitchers

San Francisco, a top-12 contender in the World Series odds, will give the ball to lefty Alex Wood. The 31-year-old is off to a strong start to the season, yielding just two runs in 9.1 innings of work, while striking out 11.

Wood produced a 10-4 record in 2021, posting solid numbers across the board. His 3.83 ERA was one of the lowest of his career, as was his 1.18 WHIP. He also posted the second highest strikeout-to-walk rate of his MLB tenure (3.9), while enemy hitters batted just .236 against him.

Wood is 5-4 all-time versus the Nats, surrendering a .264 batting average to the hitters on Washington’s current roster.

Wood vs Sanchez (2021) Stats

1-0 Record 1-1
1.93 ERA 3.06
1.29 WHIP 1.33
.250 OBA .234
3.7 SO/W Ratio 1.7

The Nationals will counter with former Giant Aaron Sanchez, who’ll make his first start of the season. Sanchez inked a one-year contract with the Nats in mid-March, and has spent the early part of the 2022 campaign in the minors. Sanchez has made three starts at AAA Rochester, posting a 1-0 record with a 3.60 ERA.

The 29-year-old pitched his lone season in San Francisco in 2021, but was released in August after missing most of the season with a variety of injuries.

Giants vs Nationals Betting Analysis

The Giants strong start to 2022 has had little to do with their offense, Friday’s result notwithstanding. They’re averaging 4.3 runs per game, but rank below league average in batting average, slugging and OPS.

No regular in their lineup is hitting .300, while only one starter is batting above .256. Entering Friday, they’d struck out 123 times, the seventh worst mark in baseball, while Joc Pederson and Brandon Belt had combined for half of their 14 total home runs.

Pitching has been their key to success. Entering Friday they’d allowed the third fewest runs in all of MLB, while posting the fourth best team ERA (2.63), and the fewest amount of homers (5).

Washington, meanwhile, has also struggled at the dish. They’re averaging just 3.73 runs per game, while batting .224. Josh Bell has been one of the few bright spots in the lineup, as his .352 average is 74 points better than that of the next best regular.

Unfortunately for the Nats, their pitching hasn’t picked them up. Washington owns the fourth-highest team ERA in the league, allowing the seventh most home runs and the most hits entering Friday’s action. No wonder they have the longest price to win the NL East in the MLB Divisional odds.

Giants vs Nationals Last 10 Meetings

Date Away Team Home Team Score
4/22/22 Giants Nationals SF, 7-1
7/11/21 Nationals Giants SF, 3-1
7/10/21 Nationals Giants SF, 10-4
7/9/21 Nationals Giants SF, 5-3
6/13/21 Giants Nationals WAS, 5-0
6/12/21 Giants Nationals SF, 2-1 F/8
6/12/21 Giants Nationals WAS, 2-0 F/7
6/11/21 Giants Nationals SF, 1-0
8/7/19 Nationals Giants WAS, 4-1
8/6/19 Nationals Giants WAS, 5-3

San Francisco Giants vs Washington Nationals Pick

The Nats have dropped three straight overall, and have scored just seven times in their past four outings. Sanchez is a wild card on the mound given he hasn’t pitched in a Major League game in eight months, and if he doesn’t last long Washington’s bottom-six ranked bullpen isn’t like to bail them out.

Another factor working against the Nats is their severe splits both at home and against lefties like Wood. Washington is hitting just .184 at home this season compared to .230 on the road. They’re slugging only .246 versus southpaws with a .537 OPS, compared to a .338 slugging percentage and .640 OPS against righties. We’ll take San Francisco in this one.

Pick: San Francisco Giants Moneyline (-165)

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